Amiodarone Dosage

Recommended Dosage for Amiodarone Injections

The initial amiodarone dosage for the injections is about 1000 mg given as a continuous infusion (a slow injection) into a vein over a 24-hour period. The dose is normally given as 150 mg over 10 minutes (15 mg per minute), followed by 360 mg over the next 6 hours (1 mg per minute), followed by 540 mg over the remaining 18 hours (0.5 mg per minute).
It should be noted that this initial amiodarone dose may vary from person to person, depending on each person's individual response to the medicine.
After the first 24 hours, a maintenance dose of amiodarone 720 mg over 24 hours (0.5 mg per minute) will be given until a healthcare provider determines the arrhythmia is adequately controlled. This may take one to three weeks of treatment. Additional doses of 150 mg may be necessary to treat any episodes of arrhythmia that occur during this time.
If continued treatment is recommended once the arrhythmia has been adequately controlled with the injections, a person will be switched over to amiodarone tablets. The initial recommended dose of the tablets in someone who has been receiving the injections will depend on how long the injection was given, as follows:
  • 800 mg to 1600 mg for people receiving amiodarone injections for less than a week
  • 600 mg to 800 mg for people receiving amiodarone injections for one to three weeks
  • 400 mg for people receiving amiodarone injections for more than three weeks.
This initial oral dosage may then be adjusted based on each person's individual response, as described earlier.

General Information on Using Amiodarone

Some considerations to keep in mind during treatment with amiodarone include the following:
  • This medication comes in the form of a tablet and as an injection. The tablet is usually taken by mouth once a day. The injection is given slowly through a tube inserted into a vein (an intravenous, or IV, infusion).
  • You will start treatment in a hospital, where a healthcare provider can closely monitor you. You will likely need to stay in the hospital for one to three weeks.
  • You should avoid drinking grapefruit juice while taking amiodarone tablets, as grapefruit juice can increase the level of amiodarone in your body.
  • You can take the tablets with or without food; however, it is important to take them the same way each time. Try taking the medicine with food if it seems to bother your stomach.
  • You should try to take your doses at about the same time each day to keep an even level of the drug in your bloodstream.
  • You will likely be started on a higher amiodarone dosage, which will be gradually reduced. Make sure you know what dose you should be taking. If you are unsure, ask your healthcare provider.
  • For the medication to work properly, it must be used as prescribed. Do not stop taking amiodarone, even if you feel well, as your irregular heartbeat may return.
  • If you are unsure about anything related to your dosage or amiodarone dosing in general, please talk with your healthcare provider or pharmacist.
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