Amiodarone Mechanism of Action

People who have certain types of irregular heartbeats called ventricular arrhythmias may benefit from amiodarone (Cordarone®, Pacerone®, Nexterone®). Although this medication is approved for use in adults, there may be times when a healthcare provider recommends it for children.
How does this drug work? A specific mechanism of action is responsible for amiodarone's effects within the body. This medicine belongs to a group of drugs known as Class III antiarrhythmics. It works by blocking potassium channels in the heart, which prevents potassium from leaving the cells of the heart muscle. This causes the heart tissue to resist any premature electrical signals that are trying to tell the heart to beat before it should.
(For more information, click Amiodarone. This article offers a complete overview of this drug's effects, safety warnings, dosing guidelines, and available strengths.)
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