Drug Interactions With Amiodarone

CYP 3A4 Inhibitor Medications
The liver breaks down amiodarone using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining amiodarone with one of these drugs may increase the level of amiodarone in your bloodstream, increasing your risk for side effects. Your healthcare provider will need to closely monitor you for side effects if you take these medications together. He or she may also want to measure the level of amiodarone in your blood using a simple blood test.
 
Dextromethorphan
Amiodarone may increase the amount of dextromethorphan in your bloodstream, increasing your risk for side effects. Talk to your healthcare provider about this potential interaction before taking these medicines together.
 
Digoxin
Amiodarone tablets increase digoxin blood levels, increasing the risk for digoxin toxicity. Your healthcare provider will need to lower your digoxin dose if you take these medications together, and closely monitor your digoxin blood levels. This interaction is less of a concern with the injectable form of amiodarone.
 
Diltiazem
Amiodarone should be used with caution in people taking diltiazem due to the risk for a dangerously low heart rate. Your healthcare provider will need to closely monitor you if you take these medicines together.
 
Fentanyl
Because amiodarone can increase fentanyl blood levels, taking these medicines together can increase your risk for serious fentanyl side effects. Talk to your healthcare provider about this potential interaction before using these medications together.
 
Fluoroquinolones
Your healthcare provider will need to closely monitor you if you take a fluoroquinolone with amiodarone, as this combination may increase the risk for potentially serious heart rhythm problems.
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