Specific Safety Concerns With Carvedilol CR

Specific Carvedilol CR Warnings and Precautions

Warnings and precautions to be aware of prior to taking carvedilol CR include the following:
  • Although carvedilol CR is approved for treating heart failure, using beta blockers (such as carvedilol CR) can, in some cases, lead to heart failure or a worsening of heart failure. Contact your healthcare provider if you notice:



  • Carvedilol CR may cause extremely low blood pressure and/or a slow heart rate in some people. Symptoms can include dizziness, lightheadedness, and fainting. These symptoms may be more noticeable when going from a sitting or lying down position to standing. If you develop any of these symptoms, contact your healthcare provider. Extreme low blood pressure is more likely to occur in people who are taking a diuretic, are on dialysis, or have diarrhea or vomiting.
  • Carvedilol CR can interact with certain medications (see Drug Interactions With Carvedilol CR).
  • Carvedilol CR may hide certain signs of hyperthyroidism. Do not stop taking carvedilol CR suddenly, as this can cause serious symptoms. Make sure to talk with your healthcare provider before stopping the drug so that it can be done in a safe manner.
  • Make sure not to drive, operate any heavy machinery, or perform any other tasks that require alertness before you know how carvedilol CR affects you.
  • People taking carvedilol CR should not stop abruptly. In clinical studies, this has been shown to increase a person's chances for developing angina (chest pain), heart attack, or serious irregular heart rhythms (arrhythmias). This risk is even greater in people with existing heart disease.
  • Beta blockers, including carvedilol CR, should be used with caution (if at all) in people with certain lung diseases, such as asthma, emphysema, chronic bronchitis, or chronic obstructive pulmonary disease (COPD). Beta blockers affect the lungs and can cause a narrowing of the airways. If you develop problems breathing or wheezing, call your healthcare provider.
  • Carvedilol CR may cause low blood sugar in some people. In some people, it may also increase blood sugar (see Coreg and Blood Sugar for more information).
  • Rarely, carvedilol CR has been known to cause a decrease in kidney function, especially in certain people, such as those with severe congestive heart failure. Let your healthcare provider know if you experience:



  • For people with allergies, carvedilol CR may increase the reaction to specific allergens, and your body may not respond to the usual doses of the medication.
  • Carvedilol CR may worsen symptoms in people with certain conditions that affect the circulation (known medically as peripheral vascular diseases).
  • If you are going to have surgery, let your healthcare provider or dentist know that you are taking carvedilol CR.


  • Medications like carvedilol CR have been reported to cause intraoperative floppy iris syndrome, a problem with the eyes that can occur during cataract surgery. Stopping carvedilol CR before surgery probably does not prevent this problem from occurring. Before having eye surgery, be sure to tell your healthcare provider if you are (or have been) on carvedilol CR. 


  • Carvedilol CR is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy. Talk to your healthcare provider about the risks and benefits of using carvedilol CR during pregnancy (see Coreg CR and Pregnancy for more information).
  • It is not known if carvedilol CR passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using carvedilol CR (see Coreg CR and Breastfeeding).
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