Cordarone Drug Interactions

Dextromethorphan
Cordarone may increase the amount of dextromethorphan in your bloodstream, increasing your risk for side effects. Talk to your healthcare provider about this potential interaction before taking these medicines together.
 
Digoxin
Cordarone increases digoxin blood levels, which increases the risk for digoxin toxicity. If you need to take these medications together, your healthcare provider will need to lower your digoxin dose and closely monitor your digoxin blood levels.
 
Diltiazem
Cordarone should be used with caution in people taking diltiazem due to the risk of a dangerously low heart rate. Your healthcare provider will need to closely monitor you if you take these medicines together.
 
Fentanyl
Because Cordarone can increase fentanyl blood levels, taking these medicines together can increase your risk for serious fentanyl side effects. Talk to your healthcare provider about this potential interaction before using fentanyl with Cordarone.
 
Fluoroquinolones
Your healthcare provider will need to closely monitor you if you take a fluoroquinolone with Cordarone, as this combination may increase the risk for potentially serious heart rhythm problems.
 
Lidocaine
Combining lidocaine with Cordarone may cause a dangerously low heart rate. Talk to your healthcare provider about this potential interaction before taking these medicines together.
 
Loratadine
There have been reports of serious heart rhythm problems occurring in people who took Cordarone with loratadine. It is probably best to avoid taking these medications together. If you do take them together, your healthcare provider will need to monitor you more closely for potential heart rhythm problems.
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Cordarone Drug Information

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