Cordarone Side Effects

It is common to experience side effects while taking Cordarone. In fact, clinical studies have shown that about 75 percent of people taking this medicine will develop some type of reaction. Some of the more commonly reported problems include fatigue, nausea, and constipation. Contact your healthcare provider if you develop more serious problems, such as vision problems, muscle weakness, or chest pain.

An Introduction to Cordarone Side Effects

Just like any medicine, Cordarone® (amiodarone hydrochloride) can cause side effects. In fact, side effects are quite common and occurred in about 75 percent of people who took Cordarone during clinical trials.
However, in many cases, reactions to this drug are minor and either require no treatment or are treated easily by you or your healthcare provider. If serious or intolerable Cordarone side effects occur, your healthcare provider may reduce your dose, or recommend you stop taking the medicine altogether. Up to 20 percent of people in Cordarone studies stopped taking the medicine because of the side effects.
(This article covers many, but not all, of the possible side effects with Cordarone. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Cordarone

The prescribing information for most prescription medications contains detailed information about the side effects that occurred in clinical trials, including the exact percentage of people who experienced side effects. However, the information for many older medications, including Cordarone, is less precise. In the case of Cordarone, the prescribing information includes general (but not exact) percentages.
In clinical studies, the most common Cordarone side effects included:
  • Neurological side effects, occurring in 20 percent to 40 percent of people, such as:
    • General feelings of discomfort or illness
    • Fatigue
    • Tremors and other uncontrolled movements
    • Muscle weakness
    • Problems with coordination and walking
    • Numbness, tingling, and burning sensations in the hands, legs, or feet
  • Gastrointestinal (GI) side effects, occurring in 10 percent to 33 percent of people, such as:


  • Skin reactions, occurring in about 15 percent of people, such as increased sensitivity to the sun.
Other common side effects, occurring in 1 percent to 9 percent of people, included:
  • Dizziness
  • Problems with eyesight
  • Increases in blood liver enzymes (which could be a sign of liver problems)
  • Breathing problems
  • Thyroid problems (hyperthyroidism or hypothyroidism)
  • Decreased sex drive (decreased libido)
  • Insomnia
  • Headache
  • Sleep problems
  • Heart failure
  • A new arrhythmia
  • Abdominal (stomach) pain
  • Liver problems
  • Flushing (sudden warmth and redness of the face, neck, and upper chest)
  • Changes in the ability to taste or smell
  • Edema (swelling due to fluid retention)
  • Changes in the amount of saliva in your mouth
  • Abnormal bleeding or bruising.
Rare side effects, occurring in less than 1 percent of people, included:
It is important to know that Cordarone stays in the body for months after you stop taking it. Therefore, you may continue to experience side effects even though you are no longer taking the medicine.
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Cordarone Drug Information

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