Disopyramide and Carbamazepine

Disopyramide (Norpace®, Norpace® CR) is a medicine approved to treat potentially life-threatening heart rhythm problems. Although this can be an effective treatment for many people, it may not be safe for use in those who are taking certain medications, including carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®).
 
As a CYP 3A4 inducer medication, carbamazepine can increase the activity of certain liver enzymes. Thus, combining carbamazepine with disopyramide can decrease the level of disopyramide in your bloodstream, potentially making it less effective. Your healthcare provider may need to closely monitor you and adjust your disopyramide dosage if needed.
 
(For more information, click Drug Interactions With Disopyramide. This article describes the problems that may occur when disopyramide is combined with carbamazepine or certain other products.)
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