Disopyramide Dosage

Using This Drug for Rapid Control of Arrhythmias

If your healthcare provider determines that your arrhythmia needs to be controlled quickly, you may be given a one-time dose of immediate-release disopyramide 300 mg at the beginning of treatment. This is called a loading dose.
If the loading dose does not control your arrhythmia within six hours, your healthcare provider may recommend you take disopyramide 200 mg every six hours as your regular dose. If this amount does not control your arrhythmia within two days, your healthcare provider may further increase it or recommend that you try a different medication.
Controlled-release disopyramide should not be used to rapidly control arrhythmias.

Switching From Immediate-Release to Controlled-Release Disopyramide

If your healthcare provider is switching you from immediate-release disopyramide to controlled-release disopyramide, you should take your first controlled-release dose six hours after your last immediate-release dose.

Disopyramide Dosing Guidelines for Children

The usual recommended dosage in children is based on the child's age and body weight, as follows:
  • For children less than 1 year old -- disopyramide 10 mg to 30 mg per kg body weight each day (about 4.5 mg to 13.6 mg per lb)
  • For children 1 to 4 years old -- disopyramide 10 mg to 20 mg per kg (about 4.5 mg to 9.1 mg per lb)
  • For children 4 to 12 years old -- disopyramide 10 mg to 15 mg per kg (about 4.5 mg to 6.8 mg per lb)
  • For children 12 to 18 years old -- disopyramide 6 mg to 15 mg per kg (about 2.7 mg to 6.8 mg per lb).
These doses are divided up throughout the day, usually given every six hours (in the case of immediate-release disopyramide). Children are normally started at the lower end of the recommended range, and the amount is then slowly adjusted based on the child's individual response.
Controlled-release disopyramide capsules should only be used in children who can swallow the capsules whole. Immediate-release disopyramide can be made into a liquid form, which may be easier for most children to take.
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Disopyramide Drug Information

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