Disopyramide Dosage

Your individual dosage of disopyramide is calculated based on factors like your age, weight, other medications you are taking, and how you respond to this drug. Disopyramide comes as a capsule and is taken every 6 or 12 hours. There is an immediate-release and a controlled-release version. The immediate-release form can also be made into a liquid suspension for people who cannot swallow the capsules.

An Introduction to Your Dosage of Disopyramide

The dose of disopyramide (Norpace®, Norpace® CR) your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to the medication
  • Your weight
  • Your age
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

What Is the Recommended Disopyramide Dosage for Adults?

The recommended initial dosage of disopyramide for treating ventricular arrhythmias in most adults is usually 600 mg a day, divided into equal doses taken every 6 or 12 hours (depending on the particular product prescribed). This initial amount will be adjusted, depending on how each individual person responds to the medication.
For example, the initial dosage may be decreased if side effects occur, or increased if the dosage does not adequately control the arrhythmia. Most people can be controlled on doses between 400 mg and 800 mg a day, taken as divided doses every 6 or 12 hours.
Lower initial doses are recommended for certain people. For example, the recommended amount for people who weigh less than 110 pounds, people with liver disease, and people with moderate kidney disease is usually 100 mg every 6 hours for people using immediate-release disopyramide or 200 mg every 12 hours for people taking the controlled-release version.
People with severe kidney disease will usually take 100 mg every 8, 12, or 24 hours, depending on the severity of the condition. These people should only use immediate-release disopyramide rather than the controlled-release form.
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Disopyramide Drug Information

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