Drug Interactions With Disopyramide

More Information on Drug Interactions With Disopyramide

The following sections explain in detail the potentially negative interactions that can occur when disopyramide is combined with any of the drugs listed above.
Anticholinergic Medications
Anticholinergic medications can cause side effects, such as:
  • Constipation
  • Dry eyes
  • Dry mouth
  • Blurred vision
  • Urinary difficulty.
Because disopyramide also causes such side effects, combining it with other anticholinergic medications may increase your risk for these symptoms. Let your healthcare provider know if your side effects are particularly bothersome or persistent.
Beta Blockers
Beta blockers work by slowing down the heart rate. Disopyramide can magnify this effect, which could cause your heart rate to slow down too much. Talk to your healthcare provider about this potential interaction if you take disopyramide with a beta blocker medication.
Certain Other Antiarrhythmia Medications
In general, disopyramide should not be taken with certain other antiarrhythmia medications (Class IA or IC antiarrhythmics) due to the risk of serious effects on the heart, including potential heart rhythm problems. These medications may sometimes be used together to treat life-threatening arrhythmias that have not responded to treatment with one medicine alone. However, the combination will require close monitoring.
CYP 3A4 Inducer Medications
The liver breaks down disopyramide using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining disopyramide with one of these drugs may decrease the level of disopyramide in your bloodstream, potentially making it less effective. Your healthcare provider may need to closely monitor you and adjust your disopyramide dosage if needed.
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