Drug Interactions With Disopyramide

CYP 3A4 Inhibitor Medications
The liver breaks down disopyramide using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining disopyramide with one of these drugs may increase the level of disopyramide in your bloodstream, increasing your risk for dangerous side effects. Your healthcare provider may need to closely monitor you and adjust your disopyramide dosage if needed.
 
Dronabinol
Combining disopyramide with dronabinol could cause an increased heart rate (tachycardia). Talk to your healthcare provider about this potential interaction before combining these drugs.
 
QT-Prolonging Medications
Disopyramide should generally not be taken with other medications that can cause QT prolongation (a certain change in the heart rhythm) because the combination may increase your risk of a life-threatening abnormal heartbeat (heart arrhythmia).
 
Medications Used to Treat Dementia
Disopyramide may decrease the effectiveness of medications used to treat dementia. If you are taking a medicine for dementia, make sure your healthcare provider knows you are also taking disopyramide.
 
Nabilone
Combining disopyramide with nabilone could cause an increased heart rate (tachycardia). Talk to your healthcare provider about this potential interaction before combining these drugs.
 
Potassium Chloride
Disopyramide may increase the risk for stomach irritation from potassium chloride tablets or capsules. Liquid or effervescent (tablets that dissolve in water) forms of potassium may be safer options for people taking disopyramide. Talk to your healthcare provider about the best form of potassium chloride for you during disopyramide treatment.
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Disopyramide Drug Information

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