Precautions and Warnings With Disopyramide

Disopyramide is associated with potentially dangerous complications, such as a potentially life-threatening heart rhythm problem, extremely low blood pressure, and dangerously low blood glucose levels. Therefore, it is important to discuss your complete medical history with your healthcare provider before beginning treatment with disopyramide. Other safety precautions include warnings for women who are pregnant or breastfeeding and people who are taking certain medications.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking disopyramide (Norpace®, Norpace® CR) if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Heart disease, such as congestive heart failure (CHF)
  • Had a heart attack in the past two years
  • Low blood pressure (hypotension)
  • Been told you have abnormal blood potassium levels (hyperkalemia or hypokalemia)
  • Heart rhythm problems other than the problem for which you are taking disopyramide, such as:
  • Wolff-Parkinson-White syndrome
  • A fast or slow heart rate
  • A heart problem known as QT prolongation or congenital long QT syndrome
  • Diabetes
  • Benign prostatic hypertrophy (BPH)
  • Glaucoma or a family history of glaucoma
  • Myasthenia gravis (a nervous system disorder that causes muscle weakness)
  • Problems urinating (urinary retention)
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
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Disopyramide Drug Information

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