Common Reactions to Enoxaparin

Common Side Effects

Enoxaparin has been studied thoroughly in clinical trials. In these studies, the reactions that occurred in a group of people taking enoxaparin were documented and then compared to the side effects that occurred in a similar group of people taking other heparin medications or a placebo (an injection with no active ingredient). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the groups taking the heparin medicines or the placebo.
In these studies, common enoxaparin side effects included:
  • Anemia -- in up to 16 percent of people
  • Bleeding (in general) -- up to 13 percent
  • Fever -- up to 8 percent
  • Fluid retention in the hands or lower limbs -- up to 6 percent
  • Injection site bleeding -- up to 5 percent
  • Nausea -- up to 2.5 percent
  • Injection site pain -- up to 2 percent
  • Blood in the urine -- up to 2 percent.
Although the studies did not seem to specifically address this issue, many people complained of injection site nodules (lumps). This problem (as well as injection site pain and bruising) may possibly be related to injection technique (How to Give Lovenox Injections for more information).

Final Thoughts

You may experience some or none of the side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any adverse reactions while taking the drug or if something "just does not seem right." While it may not be an enoxaparin side effect, your healthcare provider will be able to diagnose and treat the problem.
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