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Blocadren Drug Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when Blocadren is combined with any of the drugs listed above.
Calcium Channel Blockers
Combining Blocadren with calcium channel blockers may cause dangerously low blood pressure and, with certain calcium channel blockers, may cause a dangerously slow heart rate (bradycardia). You may need to be monitored closely if you take these medications together. In some cases, Blocadren should not be combined with a calcium channel blocker.
Stopping clonidine without stopping Blocadren could increase the risk of dangerously high blood pressure, strokes, and other serious problems. If you need to stop taking clonidine, ask your healthcare provider for further instructions.
CYP 2D6 Inhibitors
Blocadren is metabolized by a specific liver enzyme known as CYP 2D6. Medications known as CYP 2D6 inhibitors slow down the activity of this enzyme, causing an increase in the level of Blocadren in the blood. This could potentially lead to serious side effects. Different medications inhibit the enzyme to different extents; some drug interactions may be minor, while others may be quite severe. Check with your healthcare provider before combining Blocadren with a CYP 2D6 inhibitor.
Combining Blocadren with digoxin may cause a dangerously slow heart rate (bradycardia). You may need to be monitored closely if you take these medications together. In some cases, Blocadren and digoxin should not be combined.
Blocadren may decrease the effectiveness of injectable epinephrine for treating allergic reactions. If you have a serious allergy that may require treatment with epinephrine, Blocadren might not be a good choice for you.