Heart Home > More Information on Interactions With Carvedilol CR

Certain Diabetes Medications
Carvedilol CR could increase the risk of dangerously low blood sugar (hypoglycemia) that can occur with some diabetes medications. Additionally, carvedilol CR can mask some of the symptoms of low blood sugar (such as a rapid heart rate), making it less noticeable. This can lead to a very dangerous situation. You may need to monitor your blood sugar more closely, especially when starting or stopping carvedilol CR (or even when changing your dosage).
 
Cimetidine (Tagamet)
If you are taking carvedilol CR and cimetidine together, your body may metabolize carvedilol CR differently than intended. This can cause an increased level of carvedilol CR in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your carvedilol CR dose if needed.
 
Clonidine
If you take both clonidine and carvedilol CR, stopping clonidine (without stopping carvedilol CR) could increase the risk of dangerously high blood pressure, strokes, and other serious problems. It is advised to stop taking carvedilol CR several days before you gradually reduce the dose of clonidine. Do not attempt this without the approval and supervision of your healthcare provider. If you are switching from clonidine to carvedilol CR, it is advised to wait several days after stopping clonidine before starting carvedilol CR.
 
Cyclosporine
Carvedilol CR may increase the level of cyclosporine in your blood. Your healthcare provider should monitor your cyclosporine levels and adjust your cyclosporine dosage as necessary.
 
Digoxin
Combining carvedilol CR with digoxin may cause a dangerously slow heart rate (bradycardia). Additionally, carvedilol CR may increase the level of digoxin in the blood. You may need to be monitored very closely if you take these medications together. In some cases, it is not recommended to combine carvedilol CR with digoxin.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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