Heart Home > Cordarone Dosage

Available in the form of a tablet, Cordarone is taken once or twice a day to control potentially life-threatening heart rhythm problems. Your specific dosage of Cordarone will depend on the severity of your arrhythmia, how you respond to the medicine, and various other factors. You will receive your initial doses in a hospital setting, where you can be carefully monitored.

An Introduction to Dosing With Cordarone

The dosage of Cordarone® (amiodarone hydrochloride) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The severity of your arrhythmia
  • How you respond to the medication
  • Whether you have side effects.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

What Is the Recommended Cordarone Dosage?

Cordarone doses will vary for each person. The recommended initial dosage is usually between 800 mg and 1600 mg a day. This large initial amount is called a loading dose. Loading doses will be started in the hospital and will continue until the healthcare provider determines that the arrhythmia is adequately controlled. This usually takes one to three weeks.
Once the arrhythmia is adequately controlled, the Cordarone dosage will be reduced to between 600 mg and 800 mg a day for about one month, at which time the amount will be reduced again to the maintenance dose. The usual maintenance dose for most people is Cordarone 400 mg. However, some people may need higher doses (up to 600 mg a day), while others may be adequately controlled on lower maintenance doses.
Your healthcare provider will try to find the lowest effective maintenance dose that controls your arrhythmia to help reduce your risk for side effects. It may take several dosage changes to find the right amount for you. It is important that you let your healthcare provider know about any symptoms you are experiencing.
If you experience intolerable or dangerous side effects, your healthcare provider may recommend you take a lower dosage or tell you to stop taking the medicine altogether. Because a dosage reduction could cause your arrhythmia to return, you may need to be hospitalized while your dose is adjusted. Your healthcare provider may also want to check your Cordarone blood levels if you are not responding to the medication, or if you experience unexpected, serious side effects.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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