Heart Home > Cordarone Drug Interactions
Cordarone can increase blood levels of methotrexate, increasing the risk for side effects. Talk to your healthcare provider about this potential interaction before taking these medicines together.
In general, Cordarone should not be combined with most medications that can cause QT prolongation (a certain change in the heart rhythm), unless absolutely necessary, due to the risk of a life-threatening arrhythmia.
Other Arrhythmia Medications
Cordarone can increase blood levels of other antiarrhythmia medicines, increasing the risk for side effects. In general, these medicines should only be used together in people who did not adequately respond to treatment with just one antiarrhythmia drug. If you must take Cordarone with another antiarrhythmic, your healthcare provider will give you lower-than-usual doses of the other antiarrhythmia medicine.
There have been reports of serious heart rhythm problems occurring in people who took Cordarone with trazodone. You should talk to your healthcare provider about this potential interaction before taking these medications together.
Cordarone should be used with caution in people taking verapamil, due to the risk of a dangerously low heart rate. Your healthcare provider will need to closely monitor you if you take these medicines together.
Cordarone is known to increase warfarin blood levels, which increases the risk for serious bleeding problems. If you take these medicines together, your healthcare provider will need to reduce your warfarin dose and monitor you more closely.