Heart Home > Cordarone

Clinical Effects

In general, Cordarone is a very effective antiarrhythmia medication. However, the actual effectiveness of the medication depends on several factors, such as:
  • The type and severity of the arrhythmia being treated
  • Whether a person responds to and is able to tolerate the medication
  • Whether other antiarrhythmia medicines are being used.
In clinical trials, 20 percent to 40 percent of people who tolerated and responded to Cordarone well enough to continue treatment for at least a year experienced a recurrence of their arrhythmia.

When and How to Take It

Some general considerations to keep in mind during treatment with Cordarone include the following:
  • This medication comes as a tablet. It is usually taken by mouth once a day, although some people may need to take it twice a day.
  • You will probably need to stay in the hospital for at least a week when you first start taking Cordarone, so you can be closely monitored as the medication begins to work.
  • Do not drink grapefruit juice during Cordarone treatment, as it can affect the level of Cordarone in your body.
  • You can take this medication with or without food; however, it is important to take it the same way each time. Try taking it with food if it seems to bother your stomach.
  • Try to take your doses at about the same time each day to keep an even level of the drug in your bloodstream.
  • You will likely be started on a high dose of Cordarone, which will be gradually reduced. Make sure to follow your individual dosage instructions carefully.
  • For the medication to work properly, it must be taken as prescribed. Do not stop taking this medication, even if you feel well, as your irregular heartbeat may return.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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