Heart Home > Nexterone

Nexterone is used to treat serious heart rhythm problems called ventricular arrhythmias. This prescription medication is available as an injection, which is given slowly into a vein by your healthcare provider. Your dosage will depend on the severity of your condition, how you respond to this medicine, and various other factors. Possible side effects include fever, nausea, and a slow heart rate.

What Is Nexterone?

Nexterone® (amiodarone premixed injection) is a prescription injectable medication approved to treat life-threatening irregular heartbeats known as ventricular arrhythmias. It belongs to a class of medications called antiarrhythmics.
 
The active ingredient in Nexterone, amiodarone, is available in tablet form as well (Cordarone®, Pacerone®). Like the tablets, Nexterone is reserved for cases when other antiarrhythmics have not adequately controlled the arrhythmia. Nexterone may also be used in people who are unable to take amiodarone by mouth.
 
In addition, there is an injectable form of amiodarone that requires mixing prior to use. Nexterone differs from regular injectable amiodarone in that it does not need to be mixed.
 
(Click Nexterone Uses for more information on this topic, including possible off-label uses.)
 

Who Makes This Medication?

Nexterone is made by Baxter Healthcare Corporation.
 

How Does Nexterone Work?

Nexterone belongs to a group of medications known as antiarrhythmics. Most antiarrhythmic medications are further categorized using a system known as the Vaughn-Williams classification system. This system divides the medications into four general classes based on how they work.
 
Nexterone is considered a Class III antiarrhythmic; however, it has properties of all four classes and therefore works in several different ways. The most important way it works is by its Class III antiarrhythmic actions.
 
Class III antiarrhythmic medications block potassium channels in the heart, preventing potassium from leaving the cells of the heart muscle. This action prolongs the heart's refractory period, which is the period of time heart cells will not respond to a new electrical signal. By extending the refractory period, Nexterone helps the heart tissue resist any electrical signal that is trying to come through prematurely.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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