Heart Home > Pacerone

Pacerone tablets are taken once or twice a day to treat potentially life-threatening heart rhythm problems called ventricular arrhythmias. This prescription antiarrhythmic medicine is approved for use only after other treatments have failed or were not tolerated. Pacerone works by regulating electrical impulses that move through the heart muscles. Nausea, vomiting, and fatigue are some of the common side effects.

What Is Pacerone?

Pacerone® (amiodarone hydrochloride) is a prescription medication that belongs to a group of drugs known as antiarrhythmics. It is approved to treat life-threatening irregular heartbeats known as ventricular arrhythmias when other medicines have not adequately controlled the arrhythmia or were not tolerated.
(Click Pacerone Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Pacerone is made by Upsher-Smith Pharmaceuticals.

How Does Pacerone Work?

Pacerone belongs to a group of medications known as antiarrhythmics. Most antiarrhythmic medications are categorized using a system known as the Vaughn-Williams classification system. This system divides the medications into four general classes based on how they work.
Pacerone has properties of all four classes and therefore works in different ways to help control arrhythmias. However, the most important way it works is by its Class III antiarrhythmic actions.
Class III antiarrhythmic medications block potassium channels in the heart, preventing potassium from leaving the cells of the heart muscle. This action prolongs the heart's refractory period. The refractory period is the period of time the cells of the heart muscle will not respond to a new electrical signal. By extending the refractory period, Pacerone helps the heart tissue resist any electrical signal that is trying to cause the heart to beat prematurely.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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