Heart Home > Ranolazine Dosage

If you have been diagnosed with chronic angina (chest pain), your healthcare provider may prescribe ranolazine tablets. These extended-release tablets are taken twice daily, with about 12 hours between doses. The amount of ranolazine your healthcare provider prescribes will depend on how you respond to this drug and other medications you are taking.

An Introduction to Your Dosage of Ranolazine

The dose of ranolazine (Ranexa®) your healthcare provider recommends will vary, depending on several factors, including:
  • How you respond to the medication
  • Other medications you are taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Ranolazine Dosing Guidelines

The recommended starting dosage for ranolazine is 500 mg twice daily. Your healthcare provider may increase the amount up to a maximum of 1000 mg twice daily if necessary to control your angina symptoms.
If you are taking certain other medications (see Drug Interactions With Ranolazine), the maximum recommended ranolazine dosage is 500 mg twice daily.

General Information on Taking Ranolazine

Some considerations to keep in mind during treatment with ranolazine include the following:
  • Ranolazine comes in extended-release tablet form. It is taken by mouth twice a day, with about 12 hours between doses.
  • You may take this medication with or without food. If it seems to bother your stomach, try taking it with a little food.
  • Swallow the tablets whole; do not crush, break, chew, or dissolve them.
  • For the medication to work properly, it must be taken as prescribed.
  • If you are unsure about anything related to your dosage or ranolazine dosing in general, please talk with your healthcare provider or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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