Heart Home > Common Reactions to Sotalol

Common Side Effects

Sotalol has been studied thoroughly in clinical trials. In some (but not all) of these studies, the negative reactions that occur in a group of people taking the drug are documented and are then compared to those that occur in another group of people taking a placebo (a "sugar pill" with no active ingredients). This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine. Sometimes a placebo was not used, especially when used to treat life-threatening arrhythmias, as this would be unethical.
 
In these studies, the most common side effects that occurred more frequently with sotalol than with the placebo included:
 
  • Shortness of breath -- in up to 21 percent of people
  • Dizziness -- up to 20 percent
  • Fatigue -- up to 20 percent
  • Slow heart rate (bradycardia) -- up to 16 percent
  • Chest pain -- up to 16 percent
  • Heart palpitations -- up to 14 percent
  • General weakness -- up to 13 percent.
     
Other common problems (occurring in 5 to 12 percent of people) included but were not limited to:
 
  • Lightheadedness
  • Headaches
  • Nausea and/or vomiting
  • Water retention or swelling
  • Lung problems (no specific problems mentioned)
  • Sleep problems (no specific problems mentioned)
  • Diarrhea
  • An abnormal electrocardiogram (also known as an ECG or EKG)
  • Arm or leg pain
  • Indigestion or heartburn
  • Low blood pressure (hypotension)
  • Excessive sweating
  • Heart failure
  • New or worsened arrhythmia
  • Rash
  • Fainting
  • Visual problems (no specific problems mentioned).
     
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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