Mexitil Dosage

Available as capsules, Mexitil is taken every 8 or 12 hours to help control irregular heart rhythms. The initial recommended dosage of Mexitil is based on other medications you are taking, other medical conditions you have, and various other factors. The first doses are usually given in a hospital, where you can be carefully monitored and the amount can be adjusted.

An Introduction to Dosing With Mexitil

The dose of Mexitil® (mexiletine) your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to the medication
  • Other drugs you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

What Is the Recommended Mexitil Dosage?

The recommended initial dose of Mexitil is usually 200 mg every eight hours. Your healthcare provider may increase this amount by 50 mg to 100 mg, no more often than every two to three days, until a dose is found that adequately controls your arrhythmia. If you experience certain dangerous or intolerable side effects, your healthcare provider may recommend you take a lower dose.
Most people can be adequately controlled on Mexitil doses between 200 mg and 300 mg every eight hours. People with severe liver disease or significant heart failure may need lower amounts. Doses should generally not exceed 400 mg every eight hours (1200 mg in a day).
People who are adequately controlled on dosages of 300 mg or less every 8 hours may be able to take Mexitil every 12 hours. If taken every 12 hours, doses should generally not exceed 450 mg every 12 hours (900 mg in a day).

What Is the Loading Dose?

If your healthcare provider determines that your arrhythmia needs to be controlled very quickly, you may be given an initial one-time dose of Mexitil 400 mg. This is called a loading dose. Eight hours later, you will begin the usual dosing of 200 mg every eight hours. Your healthcare provider may choose to adjust the amount from there.
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Mexitil Medication Information

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