Products That Can React With Nitroglycerin Ointment

Drug Interactions With Nitroglycerin Ointment Explained

The following sections explain in detail the potentially negative interactions that can occur when nitroglycerin ointment is combined with any of the drugs listed above.
 
Alcohol
Combining alcohol with nitroglycerin ointment may increase the risk for low blood pressure (hypotension). Check with your healthcare provider before drinking alcohol while using nitroglycerin ointment.
 
Alteplase
Based on reports of a drug interaction with intravenous (IV) nitroglycerin, it is possible that nitroglycerin ointment may decrease the level of alteplase in the bloodstream, perhaps making it less effective. In the event that you need alteplase (which is sometimes used for people who are having a heart attack, blood clot, or certain types of strokes), make sure your healthcare provider knows you have been using nitroglycerin ointment.
 
Calcium Channel Blockers
Combining nitroglycerin ointment with certain calcium channel blockers may cause dangerously low blood pressure. You blood pressure may need to be closely monitored if you take these medications together.
 
Ergot Medications
Ergot medications can make nitroglycerin ointment less effective at preventing chest pain (angina), and nitroglycerin ointment may increase the level of ergot medications in the blood, increasing the risk for ergot side effects. In general, this combination of medications should be avoided if possible.
 
Phosphodiesterase Type-5 (PDE5) Inhibitors
If you are using nitroglycerin ointment, you cannot take a PDE5 inhibitor, as dangerously low blood pressure may result.
 
Rosiglitazone
One study has suggested that people taking rosiglitazone with a nitrate, such as nitroglycerin ointment, might be at an increased risk for poor blood flow to the heart, which may lead to a heart attack.
 
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Nitroglycerin Ointment Information

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