Drug Interactions With Nitroglycerin Ointment

Taking certain medications with nitroglycerin ointment may result in potentially dangerous complications. Some of these reactions can increase your risk for side effects or decrease the effectiveness of the medicines. Alcohol, calcium channel blockers, and ergot medications are among the products that can lead to drug interactions with nitroglycerin ointment.

An Overview of Nitroglycerin Ointment Interactions

Nitroglycerin ointment (Nitro-Bid^®) may react with a number of other medications. Some of the drugs that may lead to interactions with nitroglycerin ointment include but are not limited to:

Alcohol
Alteplase (Activase^®)
Calcium channel blockers, such as:

Amlodipine (Norvasc^®)
Diltiazem (Cardizem^®, Cardizem CD^®, Cardizem LA^®, Cartia XT^®, Dilacor XR^®, Dilt-CD^®, Diltia XT^®, Dilt-XR^®, Taztia XT^®, Tiazac^®)
Felodipine (Plendil^®)
Isradipine (Dynacirc^®, Dynacirc CR^®)
Nisoldipine (Sular^®)
Nicardipine (Cardene^®, Cardene SR^®)
Nifedipine (Adalat CC^®, Afeditab CR^®, Nifediac CC^®, Nifedical XL^®, Procardia^®, Procardia XL^®)
Nimodipine (Nimotop^®)
Verapamil (Calan^®, Calan SR^®, Covera-HS^®, Isoptin SR^®, Verelan^®, Verelan PM^®)

Ergot medications, such as:

Bromocriptine (Parlodel^®)
Dihydroergotamine (Migranal^®)
Ergonovine
Ergotamine (Cafergot^®, Ergomar^®)
Methylergonovine (Methergine^®)
Pergolide (Permax^®)

Phosphodiesterase type-5 (PDE5) inhibitors, such as:

Rosiglitazone (Avandia^®, Avandamet^®, Avandaryl^®).

This article refers to the nitroglycerin skin ointment that is used to treat chest pain, not the nitroglycerin ointment that is used to treat anal fissures (see Nitroglycerin Anal Ointment for more information about this medication).

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