The standard dose of Pradaxa for people with normal kidney function is 150 mg taken twice daily. However, if you have poor kidney function, your healthcare provider may reduce this dosage to 75 mg twice daily. Do not adjust your dosage or stop taking this medication without your healthcare provider's approval and supervision.
The dose of Pradaxa® (dabigatran etexilate mesylate) your healthcare provider recommends will vary, depending largely on how well your kidneys are functioning and whether you are taking certain other interacting medications.
As is always the case, do not adjust your dose unless your healthcare provider specifically tells you to do so.
For people with normal kidney function, the standard Pradaxa dosage is 150 mg twice daily. For people with poor kidney function, a lower dose (75 mg twice daily) is recommended. The drug is not recommended for people with very poor kidney function. A lower dosage (75 mg twice daily) may also be recommended for people taking dronedarone (Multaq®) or ketoconazole when taken by mouth (Nizoral®).
If you are switching to Pradaxa from warfarin (Coumadin®, Jantoven®), it is recommended that you stop warfarin first and wait to start Pradaxa until blood tests show that your International Normalized Ratio (INR) has dropped below 2.0.
If you are switching to Pradaxa from an injectable anticoagulant, Pradaxa should be started zero to two hours before the time your next injectable anticoagulant dose would have been due. If you are on a continuous intravenous (IV) drip of an anticoagulant, Pradaxa should be started as soon as the IV is turned off.
If possible, you will be taken off Pradaxa for a few days before surgery or any other invasive procedures to reduce the risk of bleeding.