Detailed Information on Drugs That Interact With Pradaxa

Pradaxa Drug Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when Pradaxa is combined with any of the drugs listed above.
 
Dronedarone
P-glycoprotein is a normal protein found throughout the body. One of its roles is to "pump" harmful or toxic substances out of the tissues so that they can be excreted through the urine or feces. P-glycoprotein helps to remove Pradaxa from the body.
 
Dronedarone is a P-glycoprotein inhibitor, which slows down the normal activity of the protein, causing the body to remove Pradaxa too slowly. This may lead to an increased risk of bleeding. Your healthcare provider may decide to monitor you for signs and symptoms of bleeding while taking Pradaxa and dronedarone together. Your healthcare provider may decide to recommend a lower-than-normal Pradaxa dosage as well.
 
Ketoconazole
Like dronedarone (discussed previously), ketoconazole is a P-glycoprotein inhibitor that may lead to high levels of Pradaxa in the body. Your healthcare provider may decide to put you on a lower-than-normal dosage of Pradaxa to account for this effect. This interaction is probably only important for ketoconazole when taken by mouth, not ketoconazole skin or shampoo products.
   
P-Glycoprotein Inducers
P-glycoprotein is a normal protein found throughout the body. One of its roles is to "pump" harmful or toxic substances out of the tissues so that they can be excreted through the urine or feces. P-glycoprotein helps to remove Pradaxa from the body.
 
However, several other medications (known as P-glycoprotein inducers) speed up the normal activity of the protein, causing the body to remove Pradaxa too quickly. This makes Pradaxa less effective. In general, Pradaxa should not be combined with such medications.
 
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Pradaxa Medication Information

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