Drug Interactions With Propafenone SR

More Detail on Drug Interactions With Propafenone SR

The following sections explain in detail the potentially negative reactions that can occur when propafenone SR is combined with any of the drugs listed above.
Propafenone SR may increase the level of aripiprazole in your blood, which could increase your risk for side effects. If you take aripiprazole, your healthcare provider may need to monitor you for aripiprazole side effects when you first start taking propafenone SR.
Certain Antiarrhythmics
Propafenone SR should not be used in combination with certain other arrhythmia medications because of the increased risk for a certain type of heart rhythm problem when these medications are combined.
Certain Beta Blockers
Propafenone SR may increase blood levels of certain beta blockers. If you take a beta blocker medication, your healthcare provider may choose to monitor your heart rate and blood pressure closely, and adjust your beta blocker dosage if needed, when you first start or stop taking propafenone SR.
Cimetidine increases blood levels of propafenone SR, which increases the risk for potentially serious side effects. If you need a medication for acid reflux or heartburn during propafenone SR treatment, ask your healthcare provider or pharmacist about a medicine that does not interact with propafenone SR.
CYP 1A2 Inhibitor Medications
The liver breaks down propafenone SR using enzymes known as CYP 1A2 enzymes, and medications known as CYP 1A2 inhibitors can decrease the activity of these enzymes. Thus, combining propafenone SR with one of these drugs may increase the level of propafenone SR in your bloodstream, increasing your risk for side effects. Your healthcare provider may need to closely monitor you if you take these medications together.
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