Drug Interactions With Ranolazine

QT-Prolonging Medications
Ranolazine can cause a change in the heart rhythm known as QT prolongation. QT prolongation increases the risk for life-threatening arrhythmias; however, studies have not shown that ranolazine increases the risk for arrhythmias. Combining ranolazine with other QT-prolonging medications might increase these risks.
 
Metformin
Ranolazine can increase the level of metformin in the blood, perhaps increasing the risk of side effects. Check with your doctor before combining these medications, as you may need a lower metformin dosage.
 
P-glycoprotein Inducers
P-glycoprotein is a protein in the body that helps remove substances, such as medications, from the tissues in the body so they can be removed through the urine or feces. Pgp helps remove ranolazine from the body. Certain medications known as Pgp inducers increase the activity of Pgp.
 
Taking ranolazine with one of these drugs causes ranolazine to be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor you more closely if you take ranolazine with a Pgp inducer to make sure it is working.
 
P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a protein in the body that helps remove substances, such as medications, from the tissues in the body so they can be removed through the urine or feces. Pgp helps remove ranolazine from the body. Certain medications known as Pgp inhibitors decrease the activity of Pgp.
 
Taking ranolazine with one of these drugs causes ranolazine to be removed more slowly, potentially increasing the amount of ranolazine in your blood and increasing your risk for serious side effects. Your healthcare provider may choose to monitor you more closely for side effects if you take ranolazine with a Pgp inhibitor. In some cases, a lower ranolazine dosage may be necessary.
 
Tricyclic Antidepressants
Ranolazine can increase the level of tricyclic antidepressants in the blood, perhaps increasing the risk of side effects. Check with your doctor before combining these medications, as you may need a lower dosage of the tricyclic antidepressant
 
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Ranolazine Drug Information

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