Precautions and Warnings With Ranolazine

If you have liver disease or a heart problem known as QT prolongation, talk to your healthcare provider before starting treatment with ranolazine. Other precautions involve the potential for serious drug interactions or liver problems. Safety warnings also apply to women who are pregnant or breastfeeding, as well as those who have certain allergies.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking ranolazine (Ranexa®) if you have:
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • A heart problem known as QT prolongation or long QT syndrome
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Ranolazine

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • Ranolazine can cause liver problems. In order to monitor for this, your healthcare provider should check your liver enzymes using a basic, standard blood test before you start ranolazine, once every three months for the first year, and then annually thereafter.
  • Ranolazine can cause a change in the heart rhythm known as QT prolongation. QT prolongation increases the risk for life-threatening arrhythmias; however, studies have not shown that ranolazine increases the risk for arrhythmias. Combining ranolazine with other QT-prolonging medications might increase these risks.
  • Ranolazine is a pregnancy Category C medication. This means that this drug might not be safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of using ranolazine during pregnancy (see Ranexa and Pregnancy for more information).
  • It is unknown if ranolazine passes through breast milk in humans. Therefore, if you are breastfeeding or plan to start, make sure to talk with your healthcare provider about using ranolazine (see Ranexa and Breastfeeding for more information).
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Ranolazine Drug Information

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