Dose of Samsca for Hyponatremia

The recommended starting Samsca® (tolvaptan) dose for treating hyponatremia (low blood sodium levels) is 15 mg once a day. However, your exact amount will be calculated based on how you respond to the medication, other medications you are taking, and other factors. Your healthcare provider may increase your dose if your sodium blood levels have not sufficiently improved within 48 hours of receiving the drug, up to a maximum Samsca dose of 60 mg a day.
Because it can be dangerous to raise blood sodium levels too quickly, you will start Samsca in the hospital, where your blood sodium levels can be monitored closely.
(Click Samsca Dosage for more details on this topic, including a list of helpful tips on taking this drug safely.)
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