Samsca Dosage

Samsca is taken once daily to increase low levels of blood sodium. The amount your healthcare prescribes will depend on how you respond to the medication, other medications you are taking, and various other factors. The starting dose of Samsca is usually 15 mg once a day. You will start this medicine in the hospital, where your blood sodium levels can be closely monitored.

An Introduction to Dosing With Samsca

The dose of Samsca® (tolvaptan) your healthcare provider recommends will vary, depending on:
  • How you respond to the medication
  • Other medications you are taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

What Is the Recommended Samsca Dosage for Hypernatremia?

The recommended initial Samsca dosage for treating hyponatremia (low blood sodium levels) is 15 mg once a day. After at least 24 hours of treatment, your healthcare provider may increase your dose if your sodium blood levels have not sufficiently improved. The maximum recommended dose of Samsca is 60 mg a day.
Raising blood sodium levels too quickly can cause a potentially serious problem known as osmotic demyelination syndrome. You will start Samsca in the hospital, where your blood sodium levels can be monitored closely. 

General Information on Taking Samsca

Some considerations to keep in mind during treatment with Samsca include the following:
  • Samsca comes in tablet form. It is usually taken by mouth once a day.
  • You can take Samsca with food or on an empty stomach.
  • You will need to start Samsca in the hospital so you can be closely monitored at the beginning of treatment.
  • Try to take this medication at the same time each day to keep an even level of the drug in your blood.
  • You should continue to drink fluids if you are thirsty during treatment with Samsca.
  • Do not drink grapefruit juice while taking this medicine. Grapefruit juice can increase the amount of Samsca in your blood.
  • For the medication to work properly, it must be taken as prescribed. Do not stop and restart this medicine on your own. If you stop taking it, you will need to restart it in the hospital.
  • If you are unsure about anything related to your Samsca dosage, please talk with your healthcare provider, nurse, or pharmacist.
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Samsca Medication Information

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