Samsca Drug Interactions

Samsca Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when any of the drugs mentioned above are combined with Samsca.
 
ACE Inhibitors
Taking Samsca with an ACE inhibitor medication may increase your risk for developing hyperkalemia (high blood potassium levels). Your healthcare provider should monitor your potassium levels closely if you take these medications together.  
 
Angiotensin II Receptor Blockers (ARBs)
Taking Samsca with an ARB medication may increase your risk for developing hyperkalemia (high blood potassium levels). Your healthcare provider should monitor your potassium levels closely if you take these medications together.  
 
Aripiprazole
Samsca may increase blood levels of aripiprazole, potentially increasing your risk for aripiprazole side effects. Your healthcare provider may need to adjust your aripiprazole dosage when you first start or stop taking Samsca. However, this will depend on why you are taking aripiprazole, and whether you have any aripiprazole side effects.
 
CYP 3A4 Inducer Medications
The liver breaks down Samsca using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Samsca with one of these drugs may decrease the level of Samsca in your body, possibly making it less effective. Your healthcare provider may need to increase your Samsca dosage if you take it with a CYP 3A4 inducer.
 
CYP 3A4 Inhibitor Medications
The liver breaks down Samsca using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Samsca with one of these drugs may increase the level of Samsca in your body, increasing your risk for side effects. Because of the risk for this interaction, the manufacturer of Samsca recommends it not be taken with certain CYP 3A4 inhibitors.
 
Desmopressin
Samsca may decrease the effectiveness of desmopressin. The manufacturer of Samsca recommends that these medicines not be taken together.
 
Digoxin
Samsca may increase blood levels of digoxin, which could increase your risk for digoxin side effects. Your healthcare provider may decide to monitor your digoxin levels using a simple blood test, and adjust your digoxin dose, especially when you start or stop taking Samsca.
 
Lomitapide
Samsca may increase the level of lomitapide in the bloodstream. Your healthcare provider may need to lower your lomitapide dosage if you take it in combination with Samsca.
 
P-glycoprotein (Pgp) Inducers
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, from the tissues in the body so they can be removed through the urine or feces. Pgp helps remove Samsca from the body. Certain other medications known as Pgp inducers increase the activity of Pgp.
 
Taking Samsca with one of these Pgp inducers causes Samsca to be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor you more closely if you take Samsca with a Pgp inducer, and increase your dose if needed.
 
P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, from the tissues in the body so they can be excreted through the urine or feces. Pgp helps remove Samsca from the body. Certain other medications known as Pgp inhibitors decrease the activity of Pgp.
 
Taking Samsca with one of these Pgp inhibitors causes Samsca to be removed more slowly, potentially increasing the amount of Samsca in your body, and increasing your risk for side effects. If you take Samsca with a Pgp inhibitor, your healthcare provider may choose to monitor you more closely, and decrease your Samsca dosage if needed. 
 
Pimozide
Samsca may increase the amount of pimozide in your body, potentially increasing your risk for side effects. Talk to your healthcare provider about this potential interaction before taking these medicines together.
 
Potassium-Sparing Diuretics
Taking Samsca with a potassium-sparing diuretic may increase your risk for developing hyperkalemia (high blood potassium levels). Your healthcare provider should monitor your potassium levels closely if you take these medications together.  
 
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Samsca Medication Information

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