Drugs That React With Sotalol

More Information on Interactions With Sotalol

The following sections explain in detail the potentially negative interactions that can occur when sotalol is combined with any of the drugs listed above.
 
Antacids
Do not take antacids that contain aluminum hydroxide or magnesium hydroxide within two hours of taking sotalol, as this may decrease the level of sotalol in the blood.
 
Calcium Channel Blockers
Combining sotalol with certain calcium channel blockers may cause a dangerously low blood pressure (hypotension), a slow heart rate (bradycardia), and heart failure. You may need to be monitored closely if you take these medications together. In some cases, sotalol and a calcium channel blocker should not be combined.
 
Certain Diuretics
Some diuretics may cause low electrolytes (such as low potassium levels), which may increase the risk of dangerous arrhythmias due to sotalol. If you take sotalol with such diuretics, your electrolytes will need to be carefully monitored.
 
Certain Other Arrhythmia Medications
Certain other arrhythmia medications should not be combined with sotalol, as this may have negative effects on the heart rhythm.
 
Clonidine
If you take both clonidine and sotalol, stopping clonidine without stopping sotalol could increase the risk of dangerously high blood pressure, strokes, and other serious problems. Sotalol should be stopped for several days before gradually reducing the dose of clonidine. Do not attempt this, however, without the approval and supervision of your healthcare provider.
 
Diabetes Medications
Sotalol may increase blood sugar, and your healthcare provider may need to adjust the dosage of your diabetes medications if this drug interaction occurs. Also, sotalol may mask some of the signs of low blood sugar (especially a racing heart); this could be dangerous for people who are prone to low blood sugar episodes.
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Sotalol Drug Information

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