Cordarone is used to control serious heart rhythm problems. It works by helping the heart tissue resist certain electrical impulses, and is approved for use only when other antiarrhythmia medications have failed or cannot be tolerated. This prescription medicine comes as a tablet that is taken once or twice daily. Some people taking it may experience side effects like nausea, vomiting, and fatigue.

What Is Cordarone?

Cordarone® (amiodarone hydrochloride) is a prescription medication approved to treat certain types of serious abnormal heartbeats known as ventricular arrhythmias. It belongs to a group of medications known as antiarrhythmics. Cordarone is approved for use when other antiarrhythmic medicines have failed or were not tolerated.
(Click Cordarone Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Brand-name Cordarone is made by Sanofi Winthrop Industrie and distributed by Wyeth Pharmaceuticals, Inc.

How Does Cordarone Work?

Cordarone belongs to a group of medications known as antiarrhythmics. Most antiarrhythmic medications are further categorized using a system known as the Vaughn-Williams classification system. This system divides the medications into four general classes based on how they work.
Cordarone has properties of all four classes and, therefore, works in different ways. However, the most important way it works is by its Class III antiarrhythmic actions.
Class III antiarrhythmic medications block potassium channels in the heart, preventing potassium from leaving the cells of the heart muscle. This action prolongs the heart's refractory period. The refractory period is the period of time the cells of the heart muscle will not respond to a new electrical signal. By extending the refractory period, Cordarone helps the heart tissue resist any electrical signal that is trying to cause the heart to beat prematurely.
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Cordarone Drug Information

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