Samsca is prescribed to treat low blood sodium levels in people with certain medical conditions. This medicine comes as a tablet and is taken once a day. Your individual dosage is calculated based on how you respond to the drug and other medications you are taking. Side effects may include thirst, dry mouth, and a lack of energy.

What Is Samsca?

Samsca® (tolvaptan) is a prescription medication approved to increase low blood sodium levels (known medically as hyponatremia) in people with certain medical conditions, including heart failure, liver disease, and syndrome of inappropriate antidiuretic hormone (SIADH). It should only be used in people who do not require urgent treatment to increase their sodium levels.
(Click Samsca Uses for more information, including possible off-label uses.)

Who Makes This Medication?

Samsca is made by Otsuka Pharmaceutical Co., Ltd.

How Does Samsca Work?

Samsca works by blocking the effects of a hormone known as vasopressin. Vasopressin helps regulate the amount of water in the body. By blocking the effects of this hormone, Samsca causes more water to be removed as urine, without causing sodium to leave the body. This results in higher blood sodium levels. 

When and How to Take It

Some general considerations to keep in mind during treatment include the following:
  • Samsca comes in tablet form. It is usually taken by mouth once a day.
  • You can take this medication with food or on an empty stomach.
  • You will need to start Samsca in the hospital so you can be closely monitored at the beginning of treatment.
  • Try to take this medication at the same time each day to keep an even level of the drug in your blood.
  • You should continue to drink fluids if you are thirsty during treatment with Samsca.
  • Do not drink grapefruit juice while taking this medicine. Grapefruit juice can increase the amount of Samsca in your blood.
  • For the medication to work properly, it must be taken as prescribed. Do not stop and restart this medicine on your own. If you stop taking it, you will need to restart it in the hospital.
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Samsca Medication Information

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